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Merrill J Egorin Selected Research

tanespimycin (17AAG)

4/2012A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors.
7/2010Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin.
10/2008A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors.
6/2008A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with paclitaxel in patients with advanced solid malignancies.
4/2007Evaluation of plasma insulin-like growth factor binding protein 2 and Her-2 extracellular domain as biomarkers for 17-allylamino-17-demethoxygeldanamycin treatment of adult patients with advanced solid tumors.
3/2007Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers.
3/2007Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.
3/2007Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
12/2005Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance.
5/2005Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers.
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Merrill J Egorin Research Topics

Disease

73Neoplasms (Cancer)
07/2019 - 03/2002
14BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
11/2013 - 07/2003
9Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
12/2012 - 07/2003
6Colorectal Neoplasms (Colorectal Cancer)
09/2010 - 10/2004
6Glioma (Gliomas)
06/2009 - 04/2004
5Pancreatic Neoplasms (Pancreatic Cancer)
02/2013 - 08/2004
5Neutropenia
01/2013 - 04/2006
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2012 - 05/2003
5Leukemia
01/2011 - 05/2003
5Fatigue
07/2010 - 05/2005
4Vomiting
09/2009 - 05/2005
4Ovarian Neoplasms (Ovarian Cancer)
11/2008 - 06/2006
4Head and Neck Neoplasms (Head and Neck Cancer)
11/2008 - 10/2004
4Carcinoma (Carcinomatosis)
08/2008 - 02/2003
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2015 - 12/2010
3Prostatic Neoplasms (Prostate Cancer)
02/2013 - 01/2003
3Disease Progression
12/2012 - 03/2007
3Neoplasm Metastasis (Metastasis)
03/2010 - 05/2004
3Glioblastoma (Glioblastoma Multiforme)
06/2009 - 12/2005
3Nausea
10/2008 - 05/2005
3Diarrhea
10/2008 - 02/2005
3Breast Neoplasms (Breast Cancer)
04/2007 - 06/2003
3Lung Neoplasms (Lung Cancer)
10/2006 - 07/2003
2Astrocytoma (Pilocytic Astrocytoma)
07/2019 - 07/2019
2Oligodendroglioma
07/2019 - 07/2019
2Hypercalcemia (Milk Alkali Syndrome)
12/2011 - 12/2002
2Lymphoma (Lymphomas)
03/2011 - 05/2009
2Acquired Immunodeficiency Syndrome (AIDS)
01/2011 - 02/2005
2Brain Neoplasms (Brain Tumor)
12/2009 - 08/2006
2Weight Loss (Weight Reduction)
06/2009 - 02/2007
2Anorexia
05/2009 - 05/2005
2Melanoma (Melanoma, Malignant)
04/2004 - 09/2002
2Urinary Bladder Neoplasms (Bladder Cancer)
02/2003 - 03/2002
1Hypoxia (Hypoxemia)
01/2015
1Chordoma
01/2015
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
11/2014
1Renal Cell Carcinoma (Grawitz Tumor)
01/2013
1Hematologic Neoplasms (Hematological Malignancy)
06/2012

Drug/Important Bio-Agent (IBA)

30Imatinib Mesylate (Gleevec)FDA Link
07/2019 - 07/2003
12Pharmaceutical PreparationsIBA
11/2013 - 03/2002
12tanespimycin (17AAG)IBA
04/2012 - 06/2003
11Paclitaxel (Taxol)FDA LinkGeneric
12/2012 - 12/2002
9VorinostatFDA Link
01/2015 - 06/2007
9Cisplatin (Platino)FDA LinkGeneric
11/2008 - 08/2002
8Docetaxel (Taxotere)FDA Link
01/2013 - 01/2003
7Proteins (Proteins, Gene)FDA Link
01/2015 - 06/2003
6Fluorouracil (Carac)FDA LinkGeneric
07/2010 - 10/2004
5Oxaliplatin (Eloxatin)FDA LinkGeneric
03/2010 - 08/2007
5PlatinumIBA
06/2009 - 09/2002
5Carboplatin (JM8)FDA LinkGeneric
06/2009 - 12/2002
5rubitecanIBA
08/2008 - 08/2004
4Tyrosine Kinase InhibitorsIBA
11/2013 - 04/2004
4DNA (Deoxyribonucleic Acid)IBA
12/2009 - 10/2004
4GemcitabineFDA Link
09/2008 - 02/2003
3DecitabineFDA Link
01/2015 - 05/2009
3Histone Deacetylase InhibitorsIBA
01/2015 - 06/2007
317- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA
07/2012 - 01/2005
3Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2010 - 01/2005
3Platelet-Derived Growth FactorIBA
12/2009 - 02/2005
39-aminocamptothecinIBA
08/2008 - 07/2005
3Cytochrome P-450 CYP3AIBA
06/2007 - 09/2004
3EnzymesIBA
03/2007 - 08/2006
3Calcitriol (Calcijex)FDA LinkGeneric
01/2003 - 08/2002
2Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2015 - 06/2008
2nilotinibFDA Link
11/2013 - 07/2009
2AndrogensIBA
02/2013 - 01/2003
2Vitamin DFDA LinkGeneric
12/2011 - 10/2006
2Bortezomib (Velcade)FDA Link
12/2011 - 08/2009
2Cytarabine (Cytosar-U)FDA LinkGeneric
12/2010 - 09/2009
2Leucovorin (Folinic Acid)FDA Link
07/2010 - 05/2009
2Temozolomide (Temodar)FDA LinkGeneric
06/2009 - 06/2008
2Hydroxyurea (Hydrea)FDA LinkGeneric
05/2009 - 12/2005
2Irinotecan (Camptosar)FDA LinkGeneric
02/2009 - 10/2008
2Capecitabine (Xeloda)FDA Link
02/2009 - 04/2005
2O(6)-benzylguanineIBA
11/2008 - 04/2005
2Phosphotransferases (Kinase)IBA
06/2008 - 10/2004
2Glutathione (Reduced Glutathione)IBA
09/2007 - 01/2003
2CamptothecinIBA
05/2006 - 08/2004
2Anti-Bacterial Agents (Antibiotics)IBA
04/2006 - 06/2003
2Antineoplastic Agents (Antineoplastics)IBA
04/2006 - 12/2002
2Tyrosine (L-Tyrosine)FDA Link
10/2004 - 05/2004
2DNA AdductsIBA
04/2004 - 09/2002
1Histone Deacetylases (Histone Deacetylase)IBA
01/2015
1Busulfan (Busulfex)FDA Link
11/2014
1kb-NB142-70IBA
02/2013
1protein kinase DIBA
02/2013
1kb-NB165-09IBA
02/2013
1benzaldehydeIBA
01/2013
1Alkylating AgentsIBA
01/2013
1NSC281612IBA
01/2013
1Benzoic Acid (Potassium Benzoate)FDA Link
01/2013
1Cyclosporine (Ciclosporin)FDA LinkGeneric
12/2012
1Growth InhibitorsIBA
07/2012
1alvocidib (flavopiridol)IBA
06/2012
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
04/2012
1BMS-275183IBA
12/2011
1Cholecalciferol (Vitamin D3)FDA Link
12/2011

Therapy/Procedure

17Therapeutics
11/2013 - 09/2002
11Drug Therapy (Chemotherapy)
07/2019 - 03/2002
1Castration
02/2012